Major Points: - Early Earth conditions and the rise of oxygen - Redox reactions - Metabolism - Environmental change relates to evolutionary pressures - Mutations + Heritability + Selection Coefficient = Evolution - Evolution is not goal oriented - How to read a phylogeny (clades, ancestral nodes, sisters) - Homologies (Orthologs and Paralogs) vs Analogies - Organisms' evolutionary history is documented in their genomes - Horizontal (Lateral) Gene Transfer - Phylogenies are testable and falsifiable explanations of observed diversity (hypotheses) that make predictions